Mercedes Unzeta Selected Research

Alzheimer Disease (Alzheimer's Disease)

3/2021	SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease.
1/2020	Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents.
1/2019	Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition.
3/2017	In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system.
1/2017	The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
1/2017	Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease.
1/2016	Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease.
1/2016	ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.
4/2015	Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids.
2/2015	Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

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Mercedes Unzeta Research Topics

Disease

25	Alzheimer Disease (Alzheimer's Disease) 03/2021 - 03/2002
8	Parkinson Disease (Parkinson's Disease) 01/2016 - 08/2002
7	Stroke (Strokes) 03/2021 - 07/2010
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 06/2008
5	Inflammation (Inflammations) 03/2021 - 05/2013
4	Cognitive Dysfunction 01/2017 - 03/2012
3	Infarction (Infarctions) 01/2019 - 07/2010
3	Ischemic Stroke 01/2019 - 07/2010
3	Gliosis 01/2017 - 02/2009
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 03/2021 - 06/2013
2	Brain Ischemia (Cerebral Ischemia) 02/2018 - 01/2014
2	Brain Injuries (Brain Injury) 02/2018 - 02/2009
2	Atherosclerosis 01/2018 - 11/2011
2	Neuroinflammatory Diseases 01/2016 - 01/2008
2	Hemorrhage 01/2014 - 07/2010
2	Hemorrhagic Stroke 01/2014 - 01/2012
2	Neuroblastoma 10/2013 - 12/2004
2	Nervous System Diseases (Neurological Disorders) 06/2013 - 03/2012
1	Herpes Zoster 01/2019
1	Hypertension (High Blood Pressure) 01/2019
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2018
1	Atherosclerotic Plaque (Atheroma) 01/2018
1	Amyloid Plaque 01/2016
1	Memory Disorders (Memory Loss) 01/2016
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 02/2015
1	Hepatic Encephalopathy 07/2014
1	Acute Liver Failure (Fulminant Hepatic Failure) 07/2014
1	Liver Diseases (Liver Disease) 07/2014
1	Body Weight (Weight, Body) 07/2014
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 01/2014
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2013
1	Multiple Sclerosis 04/2013
1	Diabetes Mellitus 10/2012
1	Cerebral Hemorrhage 01/2012

Drug/Important Bio-Agent (IBA)

15	Monoamine Oxidase (MAO)IBA 01/2020 - 08/2002
10	human AOC3 proteinIBA 03/2021 - 07/2010
7	Donepezil (Aricept)FDA LinkGeneric 01/2017 - 12/2011
6	N- ((5- (3- (1- benzylpiperidin- 4- yl)propoxy)- 1- methyl- 1H- indol- 2- yl)methyl)- N- methylprop- 2- yn- 1- amineIBA 03/2017 - 10/2013
6	N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamineIBA 01/2016 - 12/2004
6	Cholinesterases (Cholinesterase)IBA 06/2014 - 12/2011
5	Amine Oxidase (Copper-Containing)IBA 02/2018 - 03/2002
5	EnzymesIBA 02/2018 - 11/2011
5	LigandsIBA 03/2017 - 06/2013
5	Oxidoreductases (Dehydrogenase)IBA 01/2017 - 06/2012
5	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 06/2014 - 12/2011
4	Dopamine (Intropin)FDA LinkGeneric 01/2016 - 12/2004
4	AminesIBA 07/2014 - 12/2011
3	Proteins (Proteins, Gene)FDA Link 02/2018 - 01/2014
3	Scopolamine (Hyoscine)FDA Link 01/2017 - 01/2016
3	AntioxidantsIBA 01/2016 - 12/2004
3	propargylamineIBA 01/2016 - 06/2013
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 05/2013
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2018 - 01/2009
2	Amyloid (Amyloid Fibrils)IBA 01/2017 - 01/2016
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2017 - 01/2014
2	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2016 - 04/2015
2	methylamine (methylammonium)IBA 07/2014 - 06/2008
2	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2014 - 07/2010
2	InterleukinsIBA 04/2013 - 01/2008
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 06/2012 - 09/2011
2	Therapeutic UsesIBA 01/2011 - 07/2010
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 02/2003 - 08/2002
1	Multifunctional EnzymesIBA 03/2021
1	Evans Blue (Blue, Evans)FDA Link 01/2019
1	Tight Junction ProteinsIBA 01/2019
1	Claudin-5IBA 01/2019
1	Uric Acid (Urate)IBA 01/2019
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	Peptides (Polypeptides)IBA 01/2019
1	E-SelectinIBA 02/2018
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 02/2018
1	Simvastatin (Zocor)FDA LinkGeneric 02/2018
1	CholesterolIBA 02/2018
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 02/2018
1	PXS-4728AIBA 01/2018
1	AldehydesIBA 01/2018
1	ApolipoproteinsIBA 01/2018
1	Apolipoproteins E (ApoE)IBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Tacrine (Cognex)FDA Link 01/2017
1	Cholinergic Agents (Cholinergics)IBA 01/2017
1	Serotonin ReceptorsIBA 01/2017
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2017
1	TheobromineIBA 04/2015
1	Kainic Acid (Kainate)IBA 07/2014
1	Urea (Carbamide)FDA LinkGeneric 07/2014
1	Chelating AgentsIBA 06/2014
1	MetalsIBA 06/2014
1	Oxyquinoline (8 Hydroxyquinoline)FDA Link 06/2014
1	Carboxylic AcidsIBA 03/2014
1	AmidesIBA 03/2014
1	Oxygen (Dioxygen)IBA 01/2014
1	Glucose (Dextrose)FDA LinkGeneric 01/2014
1	indoleIBA 06/2013
1	HydrazinesIBA 06/2013
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 03/2012
1	PolyphenolsIBA 03/2012

Therapy/Procedure

5	Therapeutics 03/2017 - 09/2011
1	Surgical Portacaval Shunt (Portacaval Anastomosis) 07/2014
1	Transplantation 07/2014